Mole National Park is at the epicentre of Savannaland [savannatourism.com], a Northern Ghana Tourism Destination Management Area. Savannaland is dotted with unique cultural and environmental assets, among which are protected areas well connected to Mole National Park, and which are worth visiting, in particular:
Bui National Park 
Bui National Park is the third largest Wildlife Protected Area in Ghana. It covers 1,821 square kilometres and is divided by the Black Volta River. It is located in a typical woodland savannah zone in the BrongAhafo and Northern Regions of Ghana. This reserve is particularly famous for its resident hippo population in the Black Volta. Primate species like the endangered black and white colobus monkeys can be located in the Park. A variety of antelopes and birds are also present.
Gbele Resource Reserve
Gbele Resource Reserve is located in the Upper West Region of Ghana. It has a size of 565 square kilometres of open savannah woodland vegetation, the reserve is known to be the habitat of a wide range of birds. Examples of such are the Senegal parrot, beaded barbet, hornbills, purple herons, raucous pied, among others. Gbele Resource Reserve is also known to be the home of antelopes and primate species.
Wechiau Hippo Sanctuary
Wechiau Community Hippo Sanctuary is a unique community-based project that protects and preserves the wildlife and the environment of a 40 km stretch of the Black Volta River in the Upper West Region of Ghana.  The river is home to one of the two remaining hippopotamus populations in Ghana, and was created a Sanctuary by local chiefs in 1999. Apart from Wechiau’s hippos, one can experience a huge diversity of wildlife in this Sanctuary, including over 250 species of birds, bats, hedgehogs, chameleons and pythons.